The house was near Lake June Road and St. Augustine Drive in the Pleasant Grove neighborhood. It has reportedly been deemed a total loss.
A 76-year-old woman was inside the home with her 35-year-old grandson prior to the explosion. They were in different parts of the home, but managed to get out OK.
They have been taken to a nearby hospital as a precaution, and they had reportedly smelled gas earlier in the day.
Neighbors said they heard loud shakes and booms from the explosion.