Traffic has been backed up for hours, and FOX 4 is told that three people have been sent to the hospital, including two children and an adult.
The children were taken to Cook Children's in Fort Worth – one by ground and the other by air ambulance.
The adult went to John Peter Smith Hospital in Fort Worth by ground ambulance.
Police say there was a chain-reaction crash involving several cars, and then there were crashes in the backup of that initial wreck.
Currently, there's no estimated time on when the highway will reopen.