Police responded to the crash about 1:20 a.m. Monday at Lincoln Drive and Van Buren Drive.
Police said the road was wet and the woman lost control while taking a curve.
As an ambulance was pulling up to the accident scene, a pick-up truck struck it head-on. The driver and his passenger jumped out of the truck and ran away.
Police located both men and arrested one of them. No one in the ambulance was hurt.