The injury is a significant blow for the No. 8 Longhorns, who have lost three of their last four games after rising as high as No. 3 with a 13-0 start. The 6-foot-1 Enemkpali leads the Longhorns in scoring, averaging 12.4 points, and was the top rebounder in the Big 12 at 10.6 per game.
Texas recently welcomed back guard Ariel Atkins and Brianna Taylor from injury and appeared to be rounding back into shape before Enemkpali injured tore her anterior cruciate ligament in the first half of a 75-58 loss at Baylor.
Texas (14-3, 3-3 Big 12) hosts Iowa State on Saturday.